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Abstract Ultraviolet-induced skin darkening is often used as a clinical model to assess the efficacy of active ingredients aimed at modulating skin pigmentation ; targeting pigmentary skin disorders. Studying Ultraviolet (UV)-induced skin pigmentation therefore presents challenges due to the complex pigmentation kinetics involved.
Hyperpigmentation disorders are very frequent, affect the quality of life and may become a psychological burden for afflicted patients. Many anti-pigmenting or depigmenting agents are available with various efficacy and almost no comparative data. 2-mercaptonicotinoyl glycine (2-MNG) was recently proposed as a viable candidate showing safe and effective results on hyperpigmentation control in vitro and in vivo.
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