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Articles by Benson Ogunjimi
PAD4-generated citrullinated histones are triggers for autoinflammation in cryopyrin-associated periodic syndrome
Abstract Cryopyrin-associated periodic syndromes (CAPS) are autoinflammatory disorders caused by gain-of-function NLRP3 variants. Although NLRP3 inflammasomes mediate IL-1β secretion through Gasdermin D (GSDMD), we show that GSDMD deletion did not prevent autoinflammation in mice ubiquitously expressing the Nlrp3A350V variant. Inflamed skin of Nlrp3A350V-expressing GSDMD-deficient mice displayed citrullinated histone 3-containing neutrophil extracellular traps (CitH3-NETs).
Integrated drivers of basal and acute immunity in diverse human populations
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Results This study includes samples from 1,705 healthy or influenza-infected subjects from 5 countries and 8 distinct populations (Figure 1). North American populations include the Memphis cohort and the Baltimore cohort. Latin American populations include the Nicaragua cohort and the Colombia cohorts, which include subjects from the local city of Calabazo and two indigenous populations, Seywiaka and Umandita. Samples also include a European cohort from Belgium and an Asian cohort from Taiwan.
By Aisha Souquette, E. Kaitlynn Allen, Christine M. Oshansky, Emily Walker, Li Tang, Sook-San Wong, Trushar Jeevan, Stanley Pounds, Jia-Hua Qu, George Elias, Guillermina Kuan, Angel Balmaseda, Raúl Zapata, Kathryn Shaw-Saliba, Pierre Van Damme, Juan Carlos Dib, Jeremy Crawford, Benson Ogunjimi, Richard Webby, Stacey Schultz-Cherry, Andrew Pekosz, Richard Rothman, Aubree Gordon, Paul Thomas, Evadnie Rampersaud, Viggo Van Tendeloo
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Cell Reports Medicine
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Varicella zoster virus and the central nervous system - Nature Reviews Microbiology
Abstract Varicella zoster virus (VZV) causes varicella, also known as chickenpox, after which VZV remains latent in neural ganglia. VZV reactivation can result in herpes zoster, also known as shingles. In addition to its well-known effects on the peripheral nervous system, reports increasingly suggest that VZV can have potentially devastating effects on the central nervous system (CNS).
T cell receptor-centric perspective to multimodal single-cell data analysis.
Abstract The T-cell receptor (TCR) carries critical information regarding T-cell functionality. The TCR, despite its importance, is underutilized in single cell transcriptomics, with gene expression (GEx) features solely driving current analysis strategies. Here, we argue for a switch to a TCR-first approach, which would uncover unprecedented insights into T cell and TCR repertoire mechanics.
T cell receptor-centric perspective to multimodal single-cell data analysis.
Abstract The T cell receptors (TCR) carry critical information regarding T cell functionality. Yet is often overlooked in single cell experiments, which commonly focus on gene expression (GEx)-first analysis. Here we propose a dedicated TCR-first analysis for single T cell data, implemented as the STEGO.R package.
STEGO.R: an application to aid in scRNA-seq and scTCR-seq processing and analysis.
Abstract Introduction: The hypervariable T cell receptor (TCR), created through somatic recombination, allows for recognition of a diverse array of antigens. Single sequencing technologies allow capture of both the single cell expression data (scRNA-seq) with the paired single cell TCR sequencing (scTCR-seq). However, the current analytical pipelines have limited capacity to integrate both data levels.
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