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Bettina Rankl

As seen in: Wiley Online Library, Helmholtz Munich
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Articles by Bettina Rankl

Farm Dust Exposure Reduces Cytokine‐ and Rhinovirus‐Induced IL‐33 Expression in Bronchial Epithelial Cells

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By Jasmijn A. Schrumpf, Dennis K. Ninaber, Christoph Müller, Bettina Rankl
| Wiley Online Library Verified
Farm dust reduces expression of IL-33 in rhinovirus-infected and in TNF-α/IFN-γ-exposed airway epithelial cells. This effect is in part mediated through interference with the interferon-gamma receptor-JAK–STAT1 signalling pathway. To the Editor, Pre-school wheeze, attributed to respiratory viral infections, with rhinovirus (RV) being the most important risk factor, may contribute to early-onset asthma development [1, 2].
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Environmental Health, Asthma and Allergy Prevention

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By Markus Johannes Ege, Bettina Rankl, Jonathan Grigg
| Helmholtz Munich Verified
Asthma is an inflammatory disease of the airways of the lungs. It is not one disease but a syndrome consisting of many so far not well-characterized and delineated genetic and environmental determinants. The focus of our work at the Institute of Asthma and Allergy Prevention (IAP) is to develop novel asthma and allergy prevention strategies and characterize in-depth asthma phenotypes. Asthma is an inflammatory disease of the airways of the lungs.
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Farm dust reduces mucin production in rhinovirus‐infected primary bronchial epithelial cells

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By Jasmijn A. Schrumpf, Dennis K. Ninaber, Christoph Müller, Bettina Rankl
| Wiley Online Library Verified
To the Editor, Growing up on traditional farms is associated with protection against the development of wheezing, respiratory allergies, and asthma.1 Rhinovirus (RV) infections in early life are a substantial risk factor for asthma development and are linked to mucus hypersecretion in the lungs.2, 3 This results in impaired mucociliary clearance, which contributes to obstruction of (small) airways, processes implicated in asthma pathogenesis.4 Interestingly, the protective farm-effect against...
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