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Research in context Evidence before this study The effect of changing transmission intensity on the clinical presentation of malaria has been insufficiently documented and is rarely used to inform policy, even though concerns about increasing severe malaria and deaths as a consequence of a decline in the exposure to malaria in young children have long been a matter of debate.
Loading metrics Open Access Peer-reviewed Research Article Delfina F. Hlashwayo , Betuel Sigaúque, Emília V. Noormahomed, Sónia M. S. Afonso, Inácio M. Mandomando, Custódio G. Bila Delfina F. Hlashwayo, Betuel Sigaúque, Emília V. Noormahomed, Sónia M. S. Afonso, Inácio M. Mandomando, Custódio G. Bila Published: January 27, 2021 https://doi.org/10.1371/journal.pone.0245951 Figures Abstract Introduction Campylobacter spp.
Invasive pneumococcal disease (IPD) is a major cause of illness and death among children worldwide. 10-valent pneumococcal conjugate vaccine (PCV10) was introduced as part of the Mozambican routine immunization program in April 2013. We characterized the IPD burden in a rural area of Mozambique before PCV introduction and estimated the potential impact of this intervention. We conducted population-based surveillance for IPD, defined as S.
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