Oligonucleotide synthesis under mild deprotection conditions Komal Chillar, Dhananjani N. A. M. Eriyagama, Yipeng Yin, Shahien Shahsavari, Bhaskar Halami, Alexander Apostle and Shiyue Fang Abstract Over a hundred non-canonical nucleotides have been found in DNA and RNA. Many of them are sensitive toward nucleophiles. Because known oligonucleotide synthesis technologies require nucleophilic conditions for deprotection, currently there is no suitable technology for their synthesis.
