CASE REPORT article Volume 12 - 2025 | https://doi.org/10.3389/fcvm.2025.1721995 This article is part of the Research TopicPatent Foramen Ovale: Advances in Mechanisms, Diagnosis, and TherapyView all 3 articles 1 Introduction A thrombus at the foramen ovale is clinically important because it is associated with a high risk of a venous thrombus crossing a patent foramen ovale (PFO) into the arterial circulation (paradoxical embolism), potentially leading to ischemic stroke, transient ischemic...