Cruise east to west across the Volunteer State to experience some of Tennessee’s top tastes, sights, sounds, and state parks. The roughly 420-mile route follows I-40 from the Great Smoky Mountains in the east to the mighty Mississippi River in the west. If you’re planning a fly-and-drive vacation, arrive in Knoxville and depart from Memphis. Whether you start the trip on I-40 or at the Knoxville airport, it’s a short drive (about 30 miles) to Great Smoky Mountains National Park.
