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Articles by Biomedical Engineering
Mobile radiation shielding device for scatter dose reduction during portable radiography in an orthopedic ward
Loading metrics Open Access Peer-reviewed Research Article Citation: Cheewakul J, Ina N, Marshall SK, Chaichulee S (2026) Mobile radiation shielding device for scatter dose reduction during portable radiography in an orthopedic ward. PLoS One 21(11): e0362759. https://doi.org/10.1371/journal.pone.0362759 Editor: Mohamad Syazwan Mohd Sanusi, Universiti Teknologi Malaysia, MALAYSIA Received: April 30, 2026; Accepted: October 29, 2026; Published: November 13, 2026 Copyright: © 2026 Cheewakul et al.
Intrinsic and acquired transcriptional programs shape heterogeneous tumor cell responses to PARP, Akt, and CDK4/6 inhibitors
Targeted therapies are increasingly utilized across cancer types, yet their efficacy in triple-negative breast cancer (TNBC) remains limited due to the disease’s high heterogeneity and aggressive nature. In a heterogeneous tumor, treatment failure can occur due to the presence of therapy-tolerant cells, which may either be innately resistant or readily adaptive to therapy.
Organoids-on-chip for precision oncology: bridging the preclinical-clinical divide
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material.
Deciphering the role of TRPML1-mediated calcium homeostasis in innate immune cell responses during Mycobacterium tuberculosis infection
Abstract Background: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) is able to survive and replicate within host cells of the myeloid cell lineage, a critical step in the development of active TB, achieved through multiple immune evasion mechanisms. TRPML1 (Mucolipin 1), a non-selective Ca2+ ion channel belonging to the TRP superfamily, is predominantly expressed in innate immune cells and is localized intracellularly along the endosomal–lysosomal continuum.
Independent Lung Ventilation in Severe Left–Right Asymmetry: a Physiology-Driven Narrative Review of Lung-Specific Mechanical Loading
Keywords Independent lung ventilation Mechanical power Ventilator-induced lung injury Asymmetric lung disease Lung heterogeneity Regional overdistension Get full text access Log in, subscribe or purchase for full access. References: 1. Herrmann, J. ∙ Tawhai, M.H. ∙ Kaczka, D.W. Strain, strain rate, and mechanical power: An optimization comparison for oscillatory ventilation Int J Numer Method Biomed Eng. 2019; 35, e3238 2. Gattinoni, L. ∙ Tonetti, T. ∙ Cressoni, M. ...
Bioinspired Twisted Brick–Mortar Composites for Adaptive Thermo-Mechanical Impact Protection (Adv. Mater. 62/2026)
How to cite Li, Z., Gong, L., Liu, S., Li, J., Zhang, Z., Wu, J., Wang, W., Zhang, B., Li, W. and Wang, S. (2026), Bioinspired Twisted Brick–Mortar Composites for Adaptive Thermo-Mechanical Impact Protection (Adv. Mater. 62/2026). Adv. Mater., 38: e75507. https://doi.org/10.1002/adma.75507 How to cite text copied to clipboard! COPY TEXT Download Citation If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.
‘One shunt fits all?’: a comparative laboratory study of antibiotic-impregnated shunt catheters with retrospective clinical correlation
Introduction Several antibiotic-impregnated shunt catheters are commercially available, but direct comparative data on their biochemical and physical characteristics remain limited. Previous observations from our single-centre neurosurgical unit suggested that nominally similar catheter types may be associated with different rates of otherwise unexplained abdominal pain.
Synthesis of polypyrrole‒Laponite nanocomposite particles via surfactant-free aqueous chemical oxidative polymerization
Angeli A. Sopra il nero di pirrolo. Atti. Accad. Naz. Lincei Cl. Sci. Fis. Mat. Re. 1915;24:3–6. Myers RE. Chemical oxidative polymerization as a synthetic route to electrically conducting polypyrroles. J Electron Mater. 1986;15:61–9. Article CAS Google Scholar Armes SP. Optimum reaction conditions for the polymerization of pyrrole by iron(III) chloride in aqueous solution. Synth Met. 1987;20:365–71. Article CAS Google Scholar Rasmussen SC. Conjugated and conducting organic polymers: the first 150 years.
Generalizing ECG-based fatigue detection across fatigue-induction paradigms using deep learning
Abstract Introduction: Fatigue and sleepiness can arise under different experimental and behavioral conditions, yet ECG-based detection models are often evaluated only within the dataset used for development. This study investigated the participant-independent and cross-dataset performance of two ECG-derived approaches: a 1D CNN based on six HRV features and a dual-input CNN-BiLSTM combining RR interval sequences with statistical HRV descriptors.
Circadian regulation of pancreatic islet function and the transcriptome by glucocorticoid signaling
Glucocorticoids exhibit a circadian secretory pattern and act through the glucocorticoid receptor (GR), a nuclear hormone receptor that promotes cell-type-specific gene expression. However, GR targets and the regulatory role of glucocorticoids in pancreatic β-cells remain incompletely understood. We used transcriptional, epigenetic, and physiological assays to delineate the role of glucocorticoid signaling in β-cells.
Advances in therapeutic oligonucleotide conjugates
Roberts TC, Langer R, Wood MJA (2020) Advances in oligonucleotide drug delivery. Nat Rev Drug Discov 19(10):673–694. https://doi.org/10.1038/s41573-020-0075-7 Article PubMed PubMed Central CAS Google Scholar Kulkarni JA, Witzigmann D, Thomson SB, Chen S, Leavitt BR, Cullis PR et al (2021) The current landscape of nucleic acid therapeutics. Nat Nanotechnol 16(6):630–643.
How to Make Faculty Meetings More Productive, Values-Driven, and Meaningful
Leadership Training Like many other aspects of academic jobs, we are not trained to run good meetings. However, an effective meeting leader is critical to productive meetings [12]. While many department meetings are naturally led by the Chair or Department Head, it is possible that other departmental members may be able to run the meeting. Indeed, anyone can be chosen to run either parts or the whole of the department meeting.
Qualitative evaluation of decreased bowel-wall enhancement by CT as supporting ischemia in mechanical small bowel obstruction: diagnostic performance of the arterial vs. the portal phase
In our study, neither the diagnostic performance of DBE detection nor interobserver agreement was significantly better using the arterial phase compared to the portal phase in patients with mechanical SBO. Specificity was better at the portal phase (91% vs. 85%), but the difference was not statistically significant. Specificity was slightly lower than in earlier studies (94–100%) [5, 13, 17, 19].
Dual-Targeting Strategies for Chronic Inflammation
Krishma Bajaj and Ayushi Yadav contributed equally to this study. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement No new data were generated or analyzed in this review article. All information discussed is available in the cited references. References 1, , , et al., “Inflammatory Responses and Inflammation-Associated Diseases in Organs,” Oncotarget 9 (2018): 7204–7218, https://doi.org/10.18632/oncotarget.23208.
Mechanical Recycling of Hybrid Polypropylene/Recycled Carbon Fiber/Hemp Composite Wall Panels: A Comparative Study of Compression and Injection Molding
1 Introduction Circular economy is assuming importance in various applications such as automotive, packaging, and building-construction [1-3]. Global interest in adopting circular economy is a result of the growing amount of waste, which is difficult to handle, process, and ultimately ends up in landfills. Landfills result in a larger carbon footprint, leading to environmental damage and inefficient energy use.
The three-element Windkessel parameters have empirical relations that uniquely define the mechanoenergetics of cardiac muscle shortening
Introduction The heart is a mechanical pump that interacts with the arterial system. When the pressure within the left ventricle develops and exceeds the pressure load imposed by the systemic vasculature, the aortic valve opens, and the left ventricle ejects blood. During ejection, the interaction between the left ventricle and the systemic vasculature determines the ejection trajectory and the stroke volume.
Enhancing Antifungal Activity of Nitric Oxide-Releasing Polymers via the Incorporation of Piperine
1 Introduction Infection from the implantation of a biomaterial is a driver of hospital-acquired infections, or HAIs [1]. HAIs, which are infections that a patient acquires during a medical stay or procedure, can lead to increased healthcare costs, increased length of hospital stay, morbidity, and mortality, with 4–5 days added to hospital stays on average when HAIs are present, and 72,000 deaths per year in the United States [2].
Interpretable machine learning identifies predictors of IGF-1 during growth hormone therapy in boys
Abstract Objectives: Insulin-like growth factor-1 (IGF-1) is widely used to guide growth hormone (GH) therapy, yet its predictors during the maintenance phase and puberty remain incompletely understood. We aimed to predict IGF-1 standard deviation scores (SDS) at 3 and 12 months in GH-treated boys and to identify key predictors of IGF-1 dynamics using interpretable modeling approaches.
A novel hybrid and quantum-augmented variant of particle swarm optimization algorithm to solve large-scale and non-convex economic emission dispatch problems in power systems
Tian Z, Liu W, Zhang J, Sun W, Wu C (2025) EDFormer family: end-to-end multi-task load forecasting frameworks for day-ahead economic dispatch. Appl Energy 383:125319 Article Google Scholar M.I. Mohamed, A.M. Yousef, and A.A. Hafez (2025) Optimized dynamic economic dispatch incorporating dynamic generation capacity using teaching-learning-based optimizer. In: 15th International Conference on Electrical Engineering (ICEENG), Cairo, Egypt, pp. 1–6.
Restaging the primary tumor in localized pancreatic ductal adenocarcinoma after systemic therapy: a scoping review of the role of CT, FDG-PET, and CA19-9
From 4680 identified studies, 3609 were screened after deduplication, resulting in 20 included studies (Fig. 3). Study characteristics are summarized in Table 1. Most studies were retrospective (15 retrospective and 5 prospective), and CT was the most frequently used modality (75%). The most applied staging or resectability criteria were RECIST 1.1 (n = 12), National Comprehensive Cancer Network (NCCN) guidelines (n = 11), and Tumor, Node, and Metastasis (TNM) classification system (n = 6).
Advancements in Tactile Biosensors: The Role of Additive Manufacturing and Machine Learning in Biomedical Applications
1 Introduction The recent advancement of technology has had a significant impact in the biomedical field, which has allowed for new and improved diagnostic equipment for both therapy and patient monitoring [1-3]. Emerging tools and new technology can aid in the ability to provide personalized treatment based on an individual's needs through the use of real-time data that is provided from these advanced tools. Among these advances, biosensors have become fundamental tools in modern medicine [4].
Change in Carpal Tunnel Pressure With Dynamic Wrist Flexion/Extension and Radioulnar Deviation: A Cadaveric Study
1 Introduction There is a well-established association between carpal tunnel syndrome (CTS) and elevated carpal tunnel pressure (CTP). The pressure within the carpal tunnel is relatively low (< 15 mmHg) in a normal physiological state [1-3]. A higher CTP occurs in individuals with CTS [1, 3]. For example, Okutsu et al. measured CTP endoscopically and reported pressure values of 43.0 mmHg for individuals with CTS [1].
Cross-continental generalizability of EHR foundation model: predicting length of stay in an Italian hospital using US-trained embeddings
Abstract Background: Clinical Foundations Models (FMs) hold the potential to exhibit generalist medical AI capabilities, and the ability to reduce the need for explicit feature engineering. However, their evaluation often relies on locally-limited datasets, raising questions regarding their generalizability across diverse global healthcare systems, populations, and clinical practices.
Preclinical evaluation of a safety-aware multimodal robotic pipeline for human–robot interaction in post-stroke rehabilitation
Abstract Introduction: Post-stroke rehabilitation increasingly requires technologies capable of supporting intensive, measurable, and adaptable interventions while preserving clinical supervision and patient safety. This study presents a lightweight, safety-aware, and modular multimodal robotic pipeline for embodied human–robot interaction in post-stroke rehabilitation, with a first target application in hemispatial inattention.
Sliding Mode Control and Observation for Upper Limb Robotics Rehabilitation
1 Introduction Each year, millions of people around the world are affected by stroke [1], a neurological disorder that can cause both cognitive and motor disabilities [2]. Among the most severe consequences is upper limb impairment, which often has a greater impact on daily life and mental health than lower limb disability, due to the fundamental role of the arms in performing essential activities [3].
β-Catenin -Deficient Intervertebral Disc Cells Reduce Chemotactic Transcription and Myeloid Cell Recruitment to Injured Discs of Mice
1 Introduction Aging promotes intervertebral disc (IVD) degeneration (IVDD), which is a leading cause of chronic low back pain (cLBP) (Sima and Diwan 2025; Patil et al. 2018). Age-related cLBP is associated with impaired IVD healing from chronic inflammation, which promotes nerve ingrowth and immune cell recruitment (Dou et al. 2025), but the mechanisms by which aging exacerbates the development of discogenic cLBP are unclear.
Bioinspired Twisted Brick–Mortar Composites for Adaptive Thermo-Mechanical Impact Protection
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adma75226-sup-0001-SuppMat.docx27.1 MB Supporting File: adma75226-sup-0001-SuppMat.docx.
Explainability-informed patient-disjoint evaluation of deep learning for plus disease in retinopathy of prematurity with an ophthalmologist reader study
Abstract Background: Plus disease is a treatment-relevant sign of retinopathy of prematurity, but fundus images from the same infant may differ in image quality, posterior-pole coverage, and visible vascular severity. We evaluated deep-learning classification using a patient-disjoint design, within-infant variability, and an ophthalmologist reader study.
Multi-omics profiling reveals coordinated metabolic and immuno-inflammatory remodeling in a high-fat diet and single-dose streptozotocin-induced mouse model of diabetic cardiomyopathy
Background Diabetic cardiomyopathy (DCM) is a major myocardial complication of type 2 diabetes and a contributor to heart failure. However, coordinated remodeling across the cardiac transcriptome, proteome and metabolome in DCM remains incompletely defined. Methods Type 2 diabetes was induced in mice by a high-fat diet combined with single-dose streptozotocin. DCM was characterized by echocardiography, histology, transmission electron microscopy, and systemic metabolic and inflammatory assessments.
Patient-level evaluation of smartwatch-based pain and dehydration detection in nursing home residents: a prospective observational study
Abstract Introduction: Nursing home residents are at high risk for underrecognized pain and dehydration, particularly those with cognitive impairment who cannot reliably self-report symptoms. Consumer-grade smartwatches capable of continuous physiological monitoring may help detect these conditions, but their feasibility in frail older adults remains underexplored, and evaluation strategies based on random splits of repeated time windows can yield optimistically biased estimates.
Tibiotarsal mechanical behaviour is mainly a function of bone structure and not mineral density in female adolescent chickens
Abstract Introduction: Bone fragility and disuse osteoporosis in commercial egg-laying chickens is a major welfare concern. Efforts to address this have focused on eliciting increases in bone mass during growth by raising chickens in more spacious and complex housing systems that motivate increased physical activity. However, it remains unclear how these bone adaptations influence in vivo bone mechanical behaviour in chickens, namely, whole-bone stiffness and strength.
CD98hc marks a precursor of human stem cell-derived alpha cells primed for functional maturation
Abstract Introduction: Pluripotent stem cell-derived alpha cells (SC-α cells) represent a promising component of next-generation cell therapies designed to more fully recapitulate human islet function; however, heterogeneity and the presence of undesired side populations limit their functional maturity and therapeutic potential.
Microstructure and Elevated Temperature Tensile Properties of Directed Energy-Deposited 317L Austenitic Stainless Steel
K. Fang, Y. Liu, K. Luo, J. Shen, J. Lu, and E. Liu: Metals, 2026, vol. 16, p. 222. https://doi.org/10.3390/met16020222. Article CAS Google Scholar H.N. Farneze, S.S.M. Tavares, J.M. Pardal, R.F. Do Nascimento, and H.F.G. De Abreu: Eng. Fail. Anal., 2016, vol. 61, pp. 69–76. https://doi.org/10.1016/j.engfailanal.2015.08.044. Article CAS Google Scholar C. Köse: Mater. Sci. Eng. A, 2022, vol. 855, p. 143966. https://doi.org/10.1016/j.msea.2022.143966. Article CAS Google Scholar B. Meng, M. Wan, R. Zhao, Z. Zou, and H.
Biomaterials Combined With Physical Modulation Strategies for Spinal Cord Injury Repair: Material Design, Mechanism, and Challenges
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study. References 1 and , “Spinal-Cord Injury,” Lancet 359, no. 9304 (2002): 417–425, https://doi.org/10.1016/S0140-6736(02)07603-1. 2, , , et al., “Global Incidence and Characteristics of Spinal Cord Injury Since 2000-2021: A Systematic Review and Meta-Analysis,” BMC Medicine 22, no.
Composite Adaptive Control Barrier Functions for Safety-Critical Systems With Parametric Uncertainty
Conflicts of Interest The author declares no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study. References 1, , , , , and , “ Control Barrier Functions: Theory and Applications,” in European Control Conference (IEEE, 2019), 3420–3431. 2, , , and , “Control Barrier Function Based Quadratic Programs for Safety Critical Systems,” IEEE Transactions on Automatic Control 62, no.
Sensor-based human activity recognition using wrist and ankle wearables
Abstract Introduction: This article proposes using dual-body sensor placement on the right ankle and wrist with raw multi-sensor fusion (accelerometer, magnetometer, and gyroscope at 66.6 Hz) to capture complementary upper- and lower-body kinematics across nine complex daily activities and real-time integration with smart homes. Methods: Two independent datasets were obtained from participants performing different activities each at intervals of 5–10 min and with real-time labeling.
Multi-Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading
1 Introduction Knee menisci are crescent-shaped fibrocartilaginous tissues, playing essential roles in load transmission, shock absorption, and joint stability. Tears in the vascularized outer third region of the meniscus can be surgically repaired by suturing torn parts.
Profiling proteomic responses in small intestinal neuroendocrine tumor GOT1 after [ 177 Lu]Lu-DOTATATE therapy
Teoule R. Radiation-induced DNA damage and its repair. Int J radiation biology Relat Stud Phys Chem Med. 1987;51(4):573–89. Article CAS Google Scholar Saini S, Gurung P. A comprehensive review of sensors of radiation-induced damage, radiation-induced proximal events, and cell death. Immunol Rev. 2025;329(1):e13409. Article CAS PubMed Google Scholar Spetz J, Moslehi J, Sarosiek K. Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment. Curr Treat Options Cardiovasc Med.
The Impact of Copolymer Molecular Sequence on Electronic Transport (Adv. Mater. 52/2026)
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Data from more than 600 people shows resting heart rates have their own secret rhythm
You’re likely familiar with the idea of a circadian rhythm – your body’s 24-hour cycle that governs sleep and wakefulness. It turns out that resting heart rate also follows mysterious, long rhythms that run independently of the outside world. Resting heart rate is measured by how many beats per minute your heart makes while you’re calm and inactive. This measure is linked to stress, fatigue and fitness.
Data from more than 600 people shows resting heart rates have their own secret rhythm
Rochelle Ivana De Silva You’re likely familiar with the idea of a circadian rhythm – your body’s 24-hour cycle that governs sleep and wakefulness. It turns out that resting heart rate also follows mysterious, long rhythms that run independently of the outside world. Resting heart rate is measured by how many beats per minute your heart makes while you’re calm and inactive. This measure is linked to stress, fatigue and fitness.
pH-Dependent Assembly and Disassembly of β-Sheet Peptide Nanofibers Tuned by Histidine Positioning
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Targeting bromodomain and extra-terminal proteins reprograms macrophages and inhibits breast cancer progression
Abstract Introduction: Breast cancer (BC) remains a leading cause of cancer-related deaths, with resistance to therapy driving tumor progression. While immune checkpoint inhibitor (ICI) therapy is effective in some breast cancers, the heterogeneity of treatment responses is partly driven by cancer stem cells (CSCs) and an immunosuppressive tumor microenvironment (TME).
Neonatal quantitative susceptibility mapping at 7 T: towards MRI markers of developmental myelination and brain iron
1. Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom 2. London Collaborative Ultra High Field System (LoCUS), London, United Kingdom 3. Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom 4.
Gut instincts: Multi-level control and neural pathways involved in gastrointestinal interoception
Interoception is the process by which the nervous system senses and regulates the body's internal state to maintain homeostasis. Interoceptive processes in the gastrointestinal tract are carried out by multiple levels of sensory-motor control that are organized into hierarchical neural circuits, with different levels of command being engaged under various circumstances.
Anisotropic hyperelastic properties of porcine pericardium under equibiaxial loading: implications for aortic valve design
Abstract Background and objective: Bioprosthetic aortic valves with leaflets made from porcine-derived soft tissue are used to treat aortic valve disease. To improve the durability and hemodynamic performance of bioprosthetic aortic valves, it is important to understand the biomechanics of these tissues and to assess the hemodynamic performance by quantifying orifice area, downstream jet metrics, and flow parameters.
Clinical Utility of Microaxial Flow Pump Fiber-Optic Pressure Sensor for Real-Time Hemodynamic Monitoring in Cardiogenic Shock
ORIGINAL RESEARCH article Volume 13 - 2026 | doi: 10.3389/fcvm.2026.1977213 Reviewed by ORIGINAL RESEARCH article LR Lukas Ruoff 1 AS Anne-Kristin Schaefer 2 BK Barbara Karner 2 MH Martin Hermann Bernardi 3 RZ Robert Zilberszac 4 PS Peter Schellongowski 5 DZ Daniel Zimpfer 2 TS Thomas Schlöglhofer 1 1. Center for Medical Physics and Biomedical Engineering, Department of Cardiac and Thoracic Aortic Surgery, Medical University of Vienna, Vienna, Austria 2.
Deep Learning-Based Inclusion Boundary Identification Using Wave Propagation in Optical Coherence Elastography
1 Introduction Optical Coherence Elastography (OCE), as an extension of Optical Coherence Tomography (OCT), enables the estimation of tissue mechanical properties and has been widely applied in dermatology [1-4], pathology [5-7], and ophthalmology [8-10]. In vivo, OCE has been used to assess tissue biomechanics in skin [11, 12], including pathological conditions such as acne [13], where tissue stiffness serves as a key biomarker for disease progression and treatment response [14].
Nuclear localization of Toll/interleukin-1 receptor domain-containing adaptor protein reveals a previously unrecognized role in hepatic stellate cell activation
Abstract Background: The Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) is a key adaptor in Toll-like receptor signaling, classically functioning as a cytoplasmic bridging adaptor for Myeloid differentiation primary response 88 (MyD88) recruitment. While its role in inflammatory signaling is well established, its contribution to alcohol-induced liver fibrosis remains unclear.
Why you can salvage moldy cheese but never spoiled meat − a toxicologist advises on what to watch out for
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) (THE CONVERSATION) When you open the refrigerator and find a wedge of cheese flecked with green mold, or a package of chicken that smells faintly sour, it can be tempting to gamble with your stomach rather than waste food. But the line between harmless fermentation and dangerous spoilage is sharp.
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