1 Introduction cGAS is a major cytosolic dsDNA sensor[1, 2] that detects aberrantly presented cytosolic DNA, originating from both foreign pathogens including viruses[1] and bacteria,[3] as well as endogenous sources such as damaged mitochondria[4] or genomic DNA.[5] Upon binding dsDNA, cGAS is activated to produce the secondary messenger 2′3′-cGAMP,[6] which subsequently binds to the ER-resident protein STING.[7] This interaction facilitates STING trafficking to the Golgi and the recruitment...
