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Abstract Metastasis causes most cancer-related deaths in colorectal carcinoma (CRC), and microbiome markers may have prognostic value. We hypothesized that primary tumor microbiomes predict distant metastases. We analyzed 5-year metastasis-free survival (MFS) in a retrospective cohort of 900 ORIEN CRC tumor microbiomes (RNAseq). ORIEN findings were validated on an independent cohort using 16S rDNA sequencing and pathobiont-specific qPCR.
Abstract Introducing spatially tunable interactions to atomic Fermi gases makes it feasible to study two phenomena, the proximity effect and spatial Kibble-Zurek mechanism (KZM), in a unified platform. While the proximity effect of a superconductor adjacent to a normal metal corresponds to a step-function quench of the pairing interaction in real space, the spatial KZM is based on a linear drop of the interaction that can be modeled as a spatial quench.
Abstract We study binary atomic boson-fermion mixtures confined in one dimensional box potentials by few-body theory with contact interactions and mean-field many-body theory with density-density interactions. A variety of correlations and structures arise as the inter- and intraspecies interactions are tuned. Both few-body and many-body results show that miscible phase and three-chunk phase separation are directly observable in the density profiles.
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