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Apovian, C. M. & Aronne, L. J. The 2013 American Heart Association/American College of Cardiology/The Obesity Society Guideline for the management of overweight and obesity in adults: what is new about diet, drugs, and surgery for obesity? Circulation 132, 1586–1591 (2015). Torgerson, J. S., Hauptman, J., Boldrin, M. N. & Sjostrom, L.
Glucagon-like peptide-1 (GLP-1) is an incretin hormone which stimulates insulin release and inhibits glucagon secretion from the pancreas in a glucose-dependent manner. Incretin-based therapies, consisting of GLP-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors, are used for the treatment of T2D. Immunohistochemical studies for GLP-1R expression have previously been hampered by the use of unspecific polyclonal antibodies.
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