New Research, Integrative Systems TJ Hibberd, WP Yew, BN Chen, M Costa, SJ Brookes and NJ Spencer eNeuro 16 July 2020, ENEURO.0187-20.2020; DOI: https://doi.org/10.1523/ENEURO.0187-20.2020 Abstract Enteric viscerofugal neurons provide a pathway by which the enteric nervous system (ENS), otherwise confined to the gut wall, can activate sympathetic neurons in prevertebral ganglia. Firing transmitted through these pathways is currently considered fundamentally mechanosensory.