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Bolai Chen

As seen in: Nature, Science Magazine, Canadian Journal of Infectious Diseases & Medical Microbiology
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Articles by Bolai Chen

MIF-CD74 orchestrates synovial macrophage metabolic-inflammatory reprogramming by ENO2 interaction to drive osteoarthritis pathogenesis

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By Sangwoo Kim, Rui Peng, Baomei Wang, Bo Yu, Yulong Wei, Lutian Yao, Zhaowen Xue, Lei Zhang, Guihong Liang, Huajun Wang, Jianke Pan, Xiaofei Zheng, Weiyi Yang, Bolai Chen, Tao Gui, Yongpeng Lin, Zhengang Zha
| Science Magazine Verified
Reference #1 Abstract Supplementary Materials REFERENCES AND NOTES eLetters (0) Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract Synovitis is a central driver of osteoarthritis (OA) progression, yet the cellular and molecular mechanisms sustaining inflammatory circuits in the synovium remain incompletely understood.
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Tumor microenvironment-responsive metal nanotherapeutics for breast cancer chemo-/immunotherapy - NPG Asia Materials

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By Yongjun Peng, Bolai Chen
| Nature Verified
Abstract Many metal complexes not only had excellent cytotoxic antitumor effects but also could function as a positive immunomodulatory to improve antitumor effects by modifying the local tumor microenvironment. Herein, a dual-target nanotherapeutics (MP3/ACPP/AE105@NPs) with uPAR targeting and tumor microenvironment-responsive ability was developed by using AE105 as the targeting ligand and ACPP as the tumor microenvironment-responsive peptide to locate the metal complex to cells.
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