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Articles by Bolin An
AI-driven discovery and engineering of human-derived protein scaffolds for mRNA delivery
Abstract Safe and effective gene delivery remains a central challenge for therapeutic applications. While non-viral and viral vectors have enabled substantial progress, their reliance on non-human components often triggers immune responses, limiting their use in chronic treatments. Here, we develop DeepDelivery, an artificial intelligence-driven platform to identify human proteins with scaffold potential for mRNA delivery.
Author Correction: Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease
Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-025-02970-9, published online 19 January 2026. In the version of this article initially published, in Fig. 4e and associated Source Data, values for the second mouse in the L-glue group were mistakenly duplicated in the position of the fourth mouse. With the correct data, values in the Fig.
A programmable fungal platform for engineered living textiles
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract A central challenge in engineered living materials (ELMs) is the seamless integration of macroscopic structural assembly with sustained cellular viability and programmable function.
Synthetic circuits for cell ratio control
Abstract Recent advances in genetic engineering have provided diverse tools for artificially diversifying both prokaryotic and eukaryotic cell populations1,2,3,4,5,6. However, achieving precise control over the ratios of multiple cell types within a population derived from a single founder remains a major challenge.
Bio-orthogonal functionalization of bacterial cellulose combining metabolic glycoengineering and click chemistry - Nature Communications
Abstract Bacterial cellulose possesses excellent biocompatibility and mechanical strength but lacks the bioactivity needed for many biomedical and healthcare applications. To address this limitation, we develop a metabolic glycoengineering–click chemistry strategy that enables in situ incorporation of azide groups into bacterial cellulose, followed by mild and selective conjugation of alkyne-bearing functional molecules.
Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease - Nature Biotechnology
Abstract Engineering bacteria to secrete gut therapeutics has been limited by their poor autonomous sensing of pathological cues and inability to sustain localized, long-term therapeutic activity. Here we engineer nonpathogenic Escherichia coli with a blood-inducible gene circuit that secretes the barnacle-derived adhesive protein CP43K and the therapeutic gut-barrier-healing factor TFF3 in response to gastrointestinal bleeding, an indicator of severe inflammatory bowel disease (IBD).
Synthetic ratio computation for programming population composition and multicellular morphology
Abstract Recent advancements in genetic engineering have provided diverse tools for artificially synthesizing population diversity in both prokaryotic and eukaryotic systems. However, accurately controlling the ratios of multiple cell types within a population derived from a single founder remains a significant challenge.
Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings
Abstract Many biological materials form via liquid-liquid phase separation (LLPS), followed by maturation into a solid-like state. Here, using a biologically inspired assembly mechanism designed to recapitulate these sequential assemblies, we develop ultrastrong underwater adhesives made from engineered proteins containing mammalian low-complexity (LC) domains.
Modular Genetic Design of Multi-domain Functional Amyloids: Insights into Self-assembly and Functional Properties
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