ORIGINAL RESEARCH article Volume 15 - 2025 | https://doi.org/10.3389/fonc.2025.1653015 This article is part of the Research TopicRecent Advances on PET-CT in Patients with Paediatric SarcomasView all articles Introduction Ewing sarcoma (ES) accounts for approximately 40% of all bone malignancies in children and young adults and 3% of soft tissue sarcoma (STS). With advances in multimodal therapy, survival rates for patients with primary localized bone disease approach 70%-75% (1, 2).