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Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease that affects millions worldwide. Its cause remains unknown, although many physiological mechanisms are impaired. Structural abnormalities in the craniocervical region seem to be more prevalent in patients with ME/CFS, with a possible impact on intracranial pressure (ICP) and lumbar puncture (LP) measurements.
Abstract The post-covid-syndrome (PCS) is characterized by severe persisting fatigue and other long haul symptoms following COVID-19 infection. Disease-driving mechanisms are elusive, biomarkers are missing, treatment options few, and yet millions of people worldwide are affected. We hypothesized that the common complaint of polydipsia/polyuria and its attendant effect on osmolality can be quantified and identified as an unrecognized clinical feature of the PCS.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem complex disorder with major impact on the quality of life. ME/CFS comprises a broad range of manifestations including postexertional malaise, persistent fatigue, sleep dysfunction, pain, and autonomic manifestations.1,2 Disease onset is frequently attributed to an initial infectious insult,3–7 although trauma and other stressors can also be initiators.
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