Key Points Question What patient-specific, disease-related, and social factors are associated with overall survival and progression-free survival in patients with limited-stage small cell lung cancer? Findings In this post hoc secondary analysis of the CALGB 30610–RTOG 0538 randomized clinical trial, which included 638 patients randomized to twice- or once-daily radiotherapy, female sex and being younger than 70 years were associated with improved overall survival.