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Fructose consumption has been linked with insulin resistance, obesity, and diabetes, which are more prevalent in those of Māori or Pacific ethnicity compared to New Zealand European. The aim of this study was to determine whether the acute effects of fructose consumption on serum glucose, insulin, lipids and C‐reactive protein, differs according to body mass index (BMI) and/or ethnicity.
This study shows that MSU crystals have significant inhibitory effects on osteocyte viability, but no direct effect on osteocyte gene expression in vitro. In contrast, in conditioned media experiments, factors released by macrophages in response to MSU crystals have profound effects on the expression profile of osteocytes, with upregulated expression of inflammatory cytokines and mediators, and altered expression of factors involved in bone remodeling.
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