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Brenda C. M

As seen in: Oxford Academic
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Articles by Brenda C. M

lPrediction of Vancomycin Area-under-the-curve using Trough Concentrations Only: Performance Evaluation of Pediatric Population Pharmacokinetic Models

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By Birgit C. P, De Winter, Brenda C. M
| Oxford Academic Verified
In pediatric patients, vancomycin plays a pivotal role in combating infections, necessitating precise therapeutic drug monitoring to ensure efficacy and safety. The adoption of model-informed precision dosing (MIPD) has demonstrated potential in optimizing dosing strategies based on the area under the concentration-time curve (AUC ). However, predictive performance of population pharmacokinetic models using only trough concentrations to estimate AUC has not been evaluated.
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Efficacy of a loading dose of IV salbutamol in children with severe acute asthma admitted to a PICU: a randomized controlled trial - European Journal of Pediatrics

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By Corinne M. P, De Winter, Brenda C. M, van Rosmalen
| link.springer.com
Abstract The optimal dose regimen for intravenous (IV) treatment in children with severe acute asthma (SAA) is still a matter of debate. We assessed the efficacy of adding a salbutamol loading dose to continuous infusion with salbutamol in children admitted to a pediatric intensive care unit (PICU) with SAA. This multicentre, placebo-controlled randomized trial in the PICUs of four tertiary care children’s hospitals included children (2–18 years) with SAA admitted between 2017 and 2019.
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