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Articles by Brian De
Measurable Imaging-Based Changes in Enhancement of Intrahepatic Cholangiocarcinoma After Radiotherapy Reflect Physical Mechanisms of Response
npj Systems Biology and Applications 10.1038/s41540-025-00616-9 Post-print Humans, Cholangiocarcinoma, Male, Female, Retrospective Studies, Tomography, X-Ray Computed, Middle Aged, Bile Duct Neoplasms, Aged, Tumor Burden, Treatment Outcome, Adult, Aged, 80 and over, Cancer, Computational biology and bioinformatics, Oncology yes De, Brian; Dogra, Prashant; Zaid, Mohamed; et al., "Measurable Imaging-Based Changes in Enhancement of Intrahepatic Cholangiocarcinoma After Radiotherapy Reflect...
Clinical and Imaging Features of Primary Intradural Extramedullary Ewing Sarcoma
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Definitive Radiotherapy for Extracranial Oligoprogressive Metastatic Renal Cell Carcinoma as a Strategy to Defer Systemic Therapy Escalation
Objective: To study whether delivering definitive radiotherapy (RT) to sites of oligoprogression in metastatic renal cell carcinoma (mRCC) enabled deferral of systemic therapy (ST) changes without compromising disease control or survival. Patients and methods: We identified patients with mRCC who received RT to three or fewer sites of extracranial progressive disease between 2014 and 2019 at a large tertiary cancer centre.
"Late Effects of Craniospinal Irradiation Using Electron Spinal Fields " by Brian De, Marcus A Florez et al.
Abstract Purpose: For children, craniospinal irradiation (CSI) with photons is associated with significant toxic effects. The use of electrons for spinal fields is hypothesized to spare anterior structures but the long-term effects remain uncertain. We studied late effects of CSI using electrons for spinal radiation therapy (RT). Methods and materials: Records of 84 consecutive patients treated with CSI using electrons for the spine at a single institution between 1983 and 2014 were reviewed.
Benchmarking Outcomes for Molecularly Characterized Synchronous Oligometastatic Non-Small-Cell Lung Cancer Reveal
Abstract Purpose: Local consolidative therapy (LCT) for patients with synchronous oligometastatic non-small-cell lung cancer is an evolving treatment strategy, but outcomes following LCT stratified by genetic mutations have not been reported. We sought to identify genomic associations with overall survival (OS) and progression-free survival (PFS) for these patients.
Escalated-Dose Radiotherapy for Unresected Locally Advanced Pancreatic Cancer: Patterns of Care and Survival in the United States
INTRODUCTION: With locally advanced pancreatic cancer (LAPC), uncontrolled local tumor growth frequently leads to mortality. Advancements in radiotherapy (RT) techniques have enabled conformal delivery of escalated-dose RT (EDR), which may have potential local control and overall survival (OS) benefits based on retrospective and early prospective studies. With evidence for EDR emerging, we characterized the adoption of EDR across the United States and its associated outcomes.
"Definitive Liver Radiotherapy for Intrahepatic Cholangiocarcinoma with" by Brian De, Rituraj Upadhyay et al.
INTRODUCTION: Tumor-related liver failure (TRLF) is the most common cause of death in patients with intrahepatic cholangiocarcinoma (ICC). Though we previously showed that liver radiotherapy (L-RT) for locally advanced ICC is associated with less frequent TRLF and longer overall survival (OS), the role of L-RT for patients with extrahepatic metastatic disease (M1) remains undefined. We sought to compare outcomes for M1 ICC patients treated with and without L-RT.
Physician Perspectives on Telemedicine in Radiation Oncology
PURPOSE: Telemedicine enthusiasm and uptake in radiation oncology rapidly increased during the COVID-19 pandemic, but it is unclear if and how telemedicine should be used after the COVID-19 public health emergency ends is unclear. Herein, we report on our institution's provider experience after the mature adoption of telemedicine.
Brain Metastases from Biliary Tract Cancer: Case Series and Clinicogenomic Analysis
BACKGROUND: Limited data from small series have suggested that brain metastases from biliary tract cancers (BrM-BTC) affect ≤2% of patients with BTC. We sought to review our experience with patients with BrM-BTC and to identify associations of tumor-related molecular alterations with outcomes.
Measurable imaging-based changes in enhancement of intrahepatic cholangiocarcinoma after radiotherapy reflect physical mechanisms of response
BD reports honoraria from Sermo, Inc and funding from the Radiological Society of North America. EBH reports grants from Merck Serono. CMT reports a consulting/advisory role with Accuray. ACK reports ownership of shares in Aravive, Inc. PD reports honoraria from ASTRO, ASCO, Imedex, and Bayer.
Escalated‐dose radiotherapy for unresected locally advanced pancreatic cancer: Patterns of care and survival in the United States
1 INTRODUCTION Locally advanced pancreatic cancer (LAPC) accounts for approximately 80% of pancreatic cancer cases and is associated with a poor prognosis, with median survival of 13–24 months.1, 2 Mortality for patients with LAPC is driven by both early metastatic spread and uncontrolled local growth; an estimated 30% of patients with LAPC die with local progression alone, and an additional 10%–25% experience both local progression and distant spread before death.3, 4 Treatments that confer...
Predictive Model of Liver Toxicity to Aid the Personalized Selection of Proton vs Photon Therapy in Hepatocellular Carcinoma
: To develop an externally validated model for predicting liver toxicity after radiotherapy in hepatocellular carcinoma (HCC) patients that can integrate both photon and proton dose distributions with patient-specific characteristics. : Training data consisted all HCC patients treated between 2008 and 2019 at our institution (n=117, 60/40% photon/proton).
Development and validation of a recursive partitioning analysis-based pretreatment decision‐making tool identifying ideal candidates for spine stereotactic body radiation therapy - Kowalchuk - 2023 - Cancer - Wiley Online Library
ORIGINAL ARTICLE The abstract was presented at the 2022 annual meeting of the American Society for Radiation Oncology. Abstract Background This study was aimed at developing and validating a decision-making tool predictive of overall survival (OS) for patients receiving stereotactic body radiation therapy (SBRT) for spinal metastases. Methods Three hundred sixty-one patients at one institution were used for the training set, and 182 at a second institution were used for external validation.
Physician Perspectives on Telemedicine in Radiation Oncology
Introduction Telemedicine offers the potential for a range of benefits, including improvements in clinical outcomes, quality and safety, access to care, financial and operational impact, health equity, and patient, family and clinician experience. 1 Augenstein J Marks J Savuto M. Return on Health: Moving Beyond Dollars and Cents in Realizing the Value of Virtual Care. Although telemedicine was implemented in limited settings before the COVID-19 pandemic, 2 Miller RC Simone BA Lombardo JF et al.
Safety and Efficacy of Dose-Escalated Radiation Therapy With a Simultaneous Integrated Boost for the Treatment of Spinal Metastases
Purpose Intensity modulated radiation therapy (RT) for spine metastases using a simultaneous integrated boost (SSIB) was shown as an alternative to the treatment of select osseous metastases that are not amenable to spine stereotactic radiosurgery. We sought to update our clinical experience using SSIB in patients for whom dose escalation was warranted but spine stereotactic radiosurgery was not feasible.
Practical Applications of the Internet of Things in Radiation Oncology
SA-CME credits are available for this article here. Abstract As the global population ages, there will be an ever-increasing demand on health care systems worldwide for managing chronic conditions, including cancer care. A shift to automated health care solutions will be necessary to improve quality of care while also reducing resource burden to practitioners.
Late Effects of Craniospinal Irradiation Using Electron Spinal Fields for Pediatric Cancer Patients
Abstract Background For children, craniospinal irradiation (CSI) with photons is associated with significant toxicities. The use of electrons for spinal fields is hypothesized to spare anterior structures but the long-term effects remain uncertain. We studied late effects of CSI using electrons for spinal radiotherapy (RT). Methods Records of 84 consecutive patients treated with CSI using electrons for the spine at a single institution between 1983 and 2014 were reviewed.
Predictive Modeling of Survival and Toxicity in Patients With Hepatocellular Carcinoma After Radiotherapy
Abstract To stratify patients and aid clinical decision making, we developed machine learning models to predict treatment failure and radiation-induced toxicities after radiotherapy (RT) in patients with hepatocellular carcinoma across institutions. The models were developed using linear and nonlinear algorithms, predicting survival, nonlocal failure, radiation-induced liver disease, and lymphopenia from baseline patient and treatment parameters.
"Patients' Preferences for Androgen Deprivation Therapy in the Treatmen" by Brian De, Lisa M Lowenstein et al.
Home > UTHealth > GSBS > Journal Articles > 397 Medical Decision Making Policy & Practice hormone therapy, prostate adenocarcinoma, fatigue, hot flashes, impotence, libido Included in Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons COinS
Definitive Radiotherapy for Extracranial Oligoprogressive Metastatic Renal Cell Carcinoma as a Strategy to Defer Systemic Therapy Escalation
ORIGINAL ARTICLE Brian De, orcid.org/0000-0003-3468-3359 Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Search for more papers by this author Aradhana M.
Trimodality therapy for oropharyngeal cancer in the TORS era: Is there a cohort that may benefit?
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. ORIGINAL ARTICLE Trimodality therapy for oropharyngeal cancer in the TORS era: Is there a cohort that may benefit? Richard L. Bakst MD Corresponding Author E-mail address: richard.bakst@mountsinai.org Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York Correspondence Richard L.
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