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Articles by Brian Fries
Quantitative Top-Down Proteomics Reveals Significant Differences in Histone Proteoforms Between Metastatic and Nonmetastatic Colorectal Cancer Cells
BGE background electrolyte CRC colorectal cancer TDP top-down proteomics TopPIC top-down mass spectrometry-based proteoform identification and characterization 1 Introduction Colorectal cancer (CRC) is the third most prevalent cancer and the second leading cause of cancer death worldwide [1]. Its metastatic progression remains poorly understood, posing significant challenges for treatment [2].
Multi‐Omic Evaluation of PLK1 Inhibitor-Onvansertib-In Colorectal Cancer Spheroids
1 Introduction The Polo gene encodes a serine/threonine kinase first discovered in Drosophila melanogaster flies in 1988 by Claudio Sunkel and David Glover [1]. A homologous kinase was mapped to humans in 1994, giving rise to the class of Polo-like kinases (Plks) [2]. There are five Plks known to exist in humans, with Plk1 being the most studied. Plk1 is activated by phosphorylation from aurora kinase A along with the cofactor Borealin [3].
Payment Card Settlement Claim Deadline Extended to August 30, 2024 | JD Supra
A very large class action settlement has an approaching deadline for class members to file claims.
Lipidomics Profiling Reveals Differential Alterations after FAS Inhibition in 3D Colon Cancer Cell Culture Models
Cancerous cells synthesize most of their lipids de novo to keep up with their rapid growth and proliferation. Fatty acid synthase (FAS) is a key enzyme in the lipogenesis pathway that is upregulated in many cancers and has gained popularity as a druggable target of interest for cancer treatment. The first FAS inhibitor discovered, cerulenin, initially showed promise for chemotherapeutic purposes until it was observed that it had adverse side effects in mice.
[Virtual Event] State of Litigation – Part 3 - June 23rd, 1:00 pm - 3:00 pm CT | JD Supra
June 23rd, 2021 1:00 PM - 3:00 PM CT Please join Lathrop GPM for our annual State of Litigation event, being held virtually for the second year. This free, three-part webinar series will explore the latest trends in litigation, risks facing companies today, and how to manage those risks.
The Supreme Court’s Unanimous Decision Narrows TCPA’s Reach | JD Supra
The United States Supreme Court recently issued its long-awaited opinion clarifying what qualifies as an “autodialer” and is therefore governed by the Telephone Consumer Protection Act of 1991 (TCPA), potentially providing class action relief to many businesses. On April 1, 2021, the Supreme Court resolved a circuit split regarding the TCPA’s definition of “automatic telephone dialing system,” known as ATDS or autodialers.
Eleventh Circuit Breaks “New Ground” for Common Class Action Practice: Incentive Awards Banned by 1880s Supreme Court Precedent | JD Supra
In a surprising opinion, the Eleventh Circuit politely pointed out that “The Emperor has no clothes.” A common practice in class actions is for class representatives to claim and settling defendants to pay incentive awards. These are payments separate from the representative’s individual recovery, recognizing the effort to serve as class representative in class actions. These awards vary from a few hundred to tens of thousands of dollars.
Missouri Aims to Weed out Meritless Punitive Damage Claims and Reign in Consumer Protection Claims | JD Supra
Last week, the Missouri General Assembly passed and sent to Governor Mike Parson the latest bill advancing the state’s ongoing tort reform. Senate Bill No. 591 is widely considered to be a win for corporate defendants statewide and is expected to be signed by the Governor, as it was one of his legislative priorities.
COVID-19 Leads to New Class Actions | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
The Not So Sweet Side of Sugar-Based Labeling | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Privacy Alert: Let the CCPA Class Action Lawsuits Commence | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
The Big Green (1995)
Learn more People who liked this also liked... Comedy | Family 1 2 3 4 5 6 7 8 9 10 5.1/10 X A young boy refuses to accept his mother's new boyfriend, a lawyer, despite the man's attempts to win his respect, while disgruntled relatives of a criminal he prosecuted seek revenge.
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