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B7 family members and their receptors play a central role in the regulation of T cell responses through T cell costimulation and coinhibition pathways that constitute very attractive targets for the development of immunotherapeutic drugs. In this study, we report that VSIG‐3/IGSF11 is a ligand of B7 family member VISTA/PD‐1H and inhibits human T cell functions through a novel VSIG‐3/VISTA pathway.
The butyrophilins are B7-like T cell co-regulatory molecules. These molecules are of increasing interest in cancer immunotherapy as they may represent a novel subset of immune check-point regulators. In this study, we expressed the recombinant human butyrophilin 1A1 extracellular domain with a C terminal 6-His tag (BTN1A1) in NSO mouse myeloma cell line, and investigated the biological functions of the purified recombinant BTN1A1 protein in vitro.
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