Genome Maintenance Jennifer A. Calvo, Briana Fritchman, Desiree Hernandez, Nicole S. Persky, Cory M. Johannessen, Federica Piccioni, Brian A. Kelch and Sharon B. Cantor DOI: 10.1158/1541-7786.MCR-20-0828 Published June 2021 Abstract FANCJ (BRIP1/BACH1) is a hereditary breast and ovarian cancer (HBOC) gene encoding a DNA helicase. Similar to HBOC genes, BRCA1 and BRCA2, FANCJ is critical for processing DNA inter-strand crosslinks (ICL) induced by chemotherapeutics, such as cisplatin.
