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Colorectal cancer is a common cause of death in developed countries. Progression from adenoma to invasive carcinoma requires accumulation of mutations starting with the Adenomatous Polyposis Coli (Apc) gene. NF-?B signalling is a key element in cancer, mainly related to the activity of IKK?. IKK? kinase also participates in this process by mechanisms that are primarily unknown.
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