“It is an area of unmet need, and that pushes the field to develop new therapies before every ‘i’ is dotted and every ‘t’ is crossed.” Abi Pinchbeck, Commissioning Editor, Cell & Gene Therapy Insights , speaks with William Matsui, Professor, MD Anderson Cancer Center, and Bryan McClellan, Postdoctoral Research Fellow, MD Anderson Cancer Center, about a recent Nature Communications study, conducted at UT Dell Medical School, on immunotherapy resistance in pancreatic cancer.