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Articles by Bryan Strange
Human hippocampal ripples tune cortical responses based on predicted uncertainty
Abstract To encode information efficiently, our perceptual system should detect when situations are unpredictable (that is, informative) and modulate brain dynamics to prepare for encoding. Under uncertainty, there is an increased need to generate predictions about upcoming information, a process that has been proposed to require coordinated activity between the hippocampus and neocortex.
NAc-DBS selectively enhances memory updating without effect on retrieval - Neuropsychopharmacology
Abstract Deep brain stimulation (DBS) has emerged as a widely used therapeutic option when pharmacological treatments prove ineffective or refractory for psychiatric patients. The nucleus accumbens (NAc) represents a frequently targeted site in DBS interventions due to its demonstrated safety profile and therapeutic efficacy in obsessive-compulsive disorder, major depression, and anorexia nervosa. However, limited mechanistic understanding hampers its broader clinical applicability.
Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia - Alzheimer's Research & Therapy
The Vallecas Alzheimer’s Center Study (VACS) is a follow-up program for dementia patients in a specialized nursing home. The program includes clinical and MRI evaluations, as well as the possibility of post-mortem brain donation to the BT-CIEN brain bank (‘Banco de Tejidos Fundación CIEN’, in Spanish). For this study, we analyzed data from patients with at least one usable pre-mortem MRI scan (as specified below) and post-mortem brain donation.
Superagers Resist Typical Age-Related White Matter Structural Changes
aging human last-in-first-out memory neuroimaging white matter Significance Statement Episodic memory is one of the cognitive abilities most vulnerable to aging. Although memory normally declines with age, some older people may have memory performance similar to that of people 30 years younger, and this phenomenon is often conceptualized as superaging. Understanding the superager phenotype can provide insights into mechanisms of protection against age-related memory loss and dementia.
Superagers resist typical age-related white matter structural changes
Abstract Superagers are elderly individuals with the memory ability of people 30 years younger and provide evidence that age-related cognitive decline is not inevitable.
Machine learning prediction of future amyloid beta positivity in amyloid-negative individuals - Alzheimer's Research & Therapy
References Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14(4):535–62. PubMed PubMed Central Google Scholar Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, et al. Alzheimer’s disease. Lancet. 2021;397(10284):1577–90. CAS PubMed PubMed Central Google Scholar Villemagne VL, Doré V, Burnham SC, Masters CL, Rowe CC.
Superagers resist typical age-related white matter structural changes
Abstract Superagers are elderly individuals with the memory ability of people 30 years younger and provide evidence that age-related cognitive decline is not inevitable.
23 How the emotions of others capture our attention: a human amygdala disruption study
Abstract Aim We instinctively look towards faces expressing strong emotions such as fear. This survival-critical response – potentially alerting us to danger – requires rapid detection (sensory) and orientation (motor) towards a face in advance of conscious recognition of the emotion. But the neural basis of this response is unclear.
Superagers ‘more resistant to overall age-related decline than typical adults’
New evidence, published in the The Lancet Healthy Longevity journal, also shows superagers have more grey matter in key regions linked to memory function. Scientists now believe this group of people may be more resistant to overall age-related decline compared to their peers.
Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior
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