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Cell & Gene Therapy Insights 2022; 8(8), 985–992 DOI: 10.18609/cgti.2022.146 Transient transfection is a challenging and time-sensitive upstream unit operation to scale for suspension HEK293 viral vector production. For many transfection reagents, including polyethyleneimine, careful timing of mixing and hold steps is essential to process performance but challenging to maintain at relevant manufacturing scales.
Identifying key barriers in cationic polymer gene delivery to human T cells Brynn R. Olden,a Emmeline Cheng,a Yilong Chenga and Suzie H. Pun*a Abstract T cells have emerged as a therapeutically-relevant target for ex vivo gene delivery and editing. However, most commercially available reagents cannot transfect T cells and designing cationic polymers for non-viral gene delivery to T cells has resulted in moderate success.
Identifying key barriers in cationic polymer gene delivery to human T cells Brynn Olden, Emmeline Cheng, Yilong Cheng and Suzie Pun Abstract T cells have emerged as a therapeutically-relevant target for ex vivo gene delivery and editing. However, most commercially available reagents cannot transfect T cells and designing cationic polymers for non-viral gene delivery to T cells has resulted in moderate success.
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