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Abstract <p>Caffeic acid phenethyl ester (CAPE), a dietary phenolic compound derived from propolis, exhibits cardiovascular and anti-inflammatory effects; however, its mechanisms in endothelial cells remain unclear. In this study, we demonstrated that CAPE induces eNOS phosphorylation and NO production in TNF-α-stimulated endothelial cells. Mechanistically, CAPE-induced NO production is mediated by Akt, PKA, and ERK signaling pathways.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
