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Pyoderma Grangrenosum (PG) is a rare neutrophilic dermatosis with challenging diagnosis and unclear underlying mechanisms. Multifactorial causes are purposed, including neutrophilic dysfunction, aberrant cellular immunity and cytokinic activities, and genetic predispositions1. An association with a systemic disease is classically described in 25 to 75% of cases, including inflammatory bowel diseases (IBD), inflammatory rheumatological diseases (IRD) and hematological disorders.
Leg ulcers (LUs) are a chronic and severe complication of sickle-cell disease (SCD). A prospective study identifying SCD patients’ factors associated with LU complete healing and recurrence is lacking. To determine clinical and biological factors associated with SCD-LU complete healing and recurrence. This prospective, observational cohort study conducted at two Adult SCD Referral Center sites (2009–2015), included 98 consecutive patients with ? 1 LU(s) lasting ? 2 weeks.
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