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C-E Chong

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Articles by C-E Chong

Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes

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By P Venugopal, Y Lee, C-E Chong, P H Stokes
| Leukemia Verified
This is an unedited manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.
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Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes

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By C-E Chong, P Venugopal, P H Stokes, Y Lee
| Leukemia Verified
Heterozygous GATA2 mutations underlie an array of complex hematopoietic and lymphatic diseases. Analysis of the literature reporting three recurrent GATA2 germline (g) mutations (gT354M, gR396Q and gR398W) revealed different phenotype tendencies. Although all three mutants differentially predispose to myeloid malignancies, there was no difference in leukemia-free survival for GATA2 patients. Despite intense interest, the molecular pathogenesis of GATA2 mutation is poorly understood.
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