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Articles by C. Fleming
Incompleteness of the large-$N$ analysis of the $O(N)$ models: Nonperturbative cuspy fixed points and their nontrivial homotopy at finite $N$
Abstract We summarize the usual implementations of the large-N limit of O(N) models and show in detail why and how they can miss some physically important fixed points when they become singular in the limit N→∞. Using Wilson's renormalization group in its functional nonperturbative versions, we show how the singularities build up as N increases.
Linear basal cell carcinoma occurs most commonly on the lower eyelid
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湿疹患者使用多少润肤剂和类固醇乳膏,以及抑郁症和类固醇乳膏使用之间的联系
Summary 特应性皮炎 (AD) 通常简称为湿疹,是一种广泛存在的疾病,影响全球 15‐25% 的儿童和 4‐7% 的成人。AD 可引起皮肤干燥和瘙痒,对许多人来说是一种终生困扰。 AD 差异很大,在许多患者中在轻度和重度之间波动。每日两次大量使用保湿剂(称为“润肤剂”)以及涂抹在发炎皮肤区域的含类固醇乳膏有助于治疗 AD。 因此,指南建议每周使用一品脱大小装的润肤剂。然而,目前尚不清楚患者实际使用了多少保湿剂和类固醇乳膏。 为了找出这一点,来自英国的研究人员分析了电子药房配药记录,上面显示了患者正在使用多少药物。 最重要的发现如下:首先,事实上大多数患者只使用极少量的保湿剂——少于一管标准牙膏(17 克)的三分之一,其用量应该覆盖他们的整个身体,每天两次。其次,使用类固醇乳膏总体上不会超过指南建议,这是令人欣慰的。 第三,使用类固醇乳膏和治疗抑郁症之间有很强的相关性。因此,在需要大量类固醇乳膏(每月 50 克或更多)的患者中,需要定期抗抑郁治疗的患者数量几乎是使用较少量类固醇乳膏患者中需要定期抗抑郁治疗的患者数量的两倍。这一发现证实了之前关于目前患有抑郁症和更严重 AD...
How much emollient and steroid cream do eczema patients use, and the link between depression and steroid cream use
Summary Atopic dermatitis (AD), often known simply as eczema, is a widespread condition, affecting between 15‐25% of children and between 4‐7% of adults worldwide. AD causes dry and itchy skin, and for many is a life‐long affliction. AD varies enormously, fluctuating between mild and severe in many patients. Twice daily and generous application of moisturisers (called “emollients”), as well as steroid‐containing creams applied to inflamed skin areas, can help to treat AD.
3:54 PM Abstract No. 205 Systematic review of transjugular renal biopsy bleed risk and diagnostic yield: do the risks outweigh the benefits?
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. The aim of this study was to determine the incidence of bleeding complications and diagnostic yield of the transjugular renal biopsy (TJRB) procedure in the current literature.
Topical treatments in atopic dermatitis: unexpectedly low use of emollients; use of topical corticosteroid is higher in juvenile patients, higher in male vs females, and shows independent associations with asthma and depression - Choi - - British Journal
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Original Article Topical treatments in atopic dermatitis: unexpectedly low use of emollients; use of topical corticosteroid is higher in juvenile patients, higher in male vs females, and shows independent associations with asthma and depression J.
British Journal of Dermatology
银屑病是一种极为常见的疾病, 影响全世界大约 2% 人口和英国约 150 万人口。很多患者终生受到影响。银屑病通常可通过乳膏治疗。但是, 当这种治疗效果不足时, 患者可通过称为“窄波‐UVB”的特殊滤过紫外光治疗。这种治疗极为有效 (有效率 3/4) 安全, 且不需要血液检查。但是, 在很多地区并不易于获得。造成这种情况的一个原因是, 它被认为昂贵, 因为患者需要每周进行 3 次治疗, 每次数分钟, 持续数周, 且由工作人员给予治疗。在这项研究中, 作者们提取英国一家大型供应商 NHS Tayside 在 6 年中为此治疗发生的所有治疗费用。包括所有间接费用 (如养恤基金、房地产等), NHS Tayside 每人每次完整治疗平均仅花费 257 英镑。这一结果显示, 向更多患者提供此治疗极其物有所值, 并可能在很多患者中避免或延迟使用免疫抑制药物。
Cost of narrowband ultraviolet B for psoriasis
Psoriasis is a very common disease, affecting around 2% of people worldwide and 1.5 million in the UK. Many patients are affected throughout their lives. Psoriasis can often be treated with creams. However, when this is not enough patients can be treated by specially filtered ultraviolet light called “narrowband‐UVB”. This treatment is very effective in 3 out of 4 people, safe, and does not require blood testing. However, in many regions it is not readily available.
The nose as the predominant site for pemphigus foliaceous
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Meta‐analysis of the cumulative risk of endometrial malignancy and systematic review of endometrial surveillance in extended tamoxifen therapy
Optimal management of the endometrium in patients with oestrogen receptor‐positive breast cancer taking extended tamoxifen therapy (for 10 years) remains uncertain. A meta‐analysis was performed to determine the cumulative risk ratio (RR) for endometrial malignancy following extended compared with standard tamoxifen treatment.
Meta‐analysis of the cumulative risk of endometrial malignancy and systematic review of endometrial surveillance in extended tamoxifen therapy
Optimal management of the endometrium in patients with oestrogen receptor‐positive breast cancer taking extended tamoxifen therapy (for 10 years) remains uncertain. A meta‐analysis was performed to determine the cumulative risk ratio (RR) for endometrial malignancy following extended compared with standard tamoxifen treatment.
Meta‐analysis of the diagnostic accuracy of ultrasound‐guided fine‐needle aspiration and core needle biopsy in diagnosing axillary lymph node metastasis - Balasubramanian - 2018 - BJS - Wiley Online Library
Axillary lymph node status remains a significant prognostic indicator in breast cancer. Here, the diagnostic accuracy of ultrasound‐guided fine‐needle aspiration (US‐FNA) and ultrasound‐guided core needle biopsy (US‐CNB) in axillary staging was compared. A comprehensive search was undertaken of all published studies comparing the diagnostic accuracy of US‐CNB and US‐FNA of axillary lymph nodes in breast cancer.
Meta‐analysis of the cumulative risk of endometrial malignancy and systematic review of endometrial surveillance in extended tamoxifen therapy
The aim of the present review was twofold. The first objective was to perform a meta‐analysis to determine the cumulative risk ratio (RR) for endometrial malignancy in extended compared with standard adjuvant tamoxifen therapy for breast cancer. The second was to undertake a systematic review of evidence for the accuracy and value of routine endometrial surveillance in patients receiving tamoxifen.
Narrowband‐UVB treatment for psoriasis is highly economical and causes significant savings in cost for topical treatments
Data linkage of (i) comprehensive treatment records, (ii) prescribing data for all NB‐UVB treatment episodes spanning six years in a population of 420,000. Minimisation of data fluctation by: (a) compiling data from 4 independent treatment sites, (b) use of drug prescribing unrelated to psoriasis as negative control.
Narrowband ultraviolet B treatment for psoriasis is highly economical and causes significant savings in cost for topical treatments
Here we apply our uniquely comprehensive set of data to compile the expenses incurred by a healthcare provider for the treatment of psoriasis with NB‐UVB based on actual costs, taking into account savings achieved through reduced need for topical psoriasis treatment.
A Phase II Toxicity End Point Trial (ICORG 99-09) of Accelerated Dose-escalated Hypofractionated Radiation in Non-small Cell Lung Cancer
Publication HistoryPublished online: October 30, 2017Accepted: September 21, 2017; Received in revised form: September 18, 2017; Received: March 24, 2017;
Safety, complications and patients’ acceptance of Mohs micrographic surgery under local anaesthesia: results from the U.K. MAPS (Mohs Acceptance and Patient Safety) Collaboration Group - Hussain - 2017 - British Journal of Dermatology - Wiley Online Libra
Previous article in Early View: Paediatric primary cutaneous marginal zone B-cell lymphoma: does it differ from its adult counterpart? Previous article in Early View: Paediatric primary cutaneous marginal zone B-cell lymphoma: does it differ from its adult counterpart?
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