1 INTRODUCTION Common variable immunodeficiency disorders (CVID) and large granular lymphocytes leukemia (LGLL) are two distinct entities characterized by heterogeneous clinical presentations from a very indolent clinic to severe manifestations requiring therapeutic management.1 CVID is considered in the presence of hypogammaglobulinemia usually <5 g/L, in the context of recurrent infections (frequently upper and lower respiratory airway infections and/or digestive diseases such as Giardia...