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Abstract Real geography is continuous, but standard models in population genetics are based on discrete, well-mixed populations. As a result, many methods of analyzing genetic data assume that samples are a random draw from a well-mixed population, but are applied to clustered samples from populations that are structured clinally over space.
Minor allele frequency thresholds strongly affect population structure inference with genomic datasets Ethan B. Linck, C. J. Battey bioRxiv 188623; doi: https://doi.org/10.1101/188623
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