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Modulation of H+/H− exchange in iridium-hydride 2-hydroxypyridine complexes by remote Lewis acids† A series of iridium hydride complexes featuring dihydrogen bonding are presented and shown to undergo rapid H+/H− exchange (1240 s−1 at 25 °C). We demonstrate that the H+/H− exchange rate can be modified by post-synthetic modification at a remote site using BH3, Zn(C6F5)2, and [Me3O][BF4].
Rhinovirus (RV) infection in asthma induces varying degrees of airway inflammation (e.g. neutrophils), but the underlying mechanisms remain unclear. The major goal was to determine the role of genetic variation [e.g. single nucleotide polymorphisms (SNPs)] of Toll-interacting protein (Tollip) in airway epithelial responses to RV in a type 2 cytokine milieu. DNA from blood of asthmatic and normal subjects was genotyped for Tollip SNP rs5743899 AA, AG and GG genotypes.
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