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Articles by C. Ruffmann
Detection of alpha‐synuclein conformational variants from gastro‐intestinal biopsy tissue as a potential biomarker for Parkinson's disease
Gastrointestinal (GI) α‐synuclein (aSyn) detection as a potential biomarker of Parkinson's disease (PD) is challenged by conflicting results of recent studies. To increase sensitivity and specificity, we applied three techniques to detect different conformations of aSyn in GI biopsies obtained from a longitudinal, clinically well‐characterized cohort of PD patients and healthy controls (HC). A total of 163 tissue blocks were collected from 51 PD patients (113 blocks) and 21 HC (50 blocks).
Detection of alpha‐synuclein conformational variants from gastro‐intestinal biopsy tissue as a potential biomarker for Parkinson's disease
This study was designed to tackle the limitations and issues emerging from previous studies on GI aSyn detection as a potential biomarker for PD. We detected aSyn in paraffin‐embedded GI biopsies from longitudinally followed PD patients and healthy controls (HC) participating in the Oxford Discovery study 23 using three different techniques: conventional IHC, our recently developed Proximity Ligation Assay for aSyn (AS‐PLA) 24 and Paraffin Embedded Tissue Blot for aSyn (AS‐PET‐blot) 25 .
Detection of alpha‐synuclein conformational variants from gastro‐intestinal biopsy tissue as a potential biomarker for Parkinson's disease
Abstract Aims Gastrointestinal (GI) α‐synuclein (aSyn) detection as a potential biomarker of Parkinson's disease (PD) is challenged by conflicting results of recent studies. To increase sensitivity and specificity, we applied three techniques to detect different conformations of aSyn in GI biopsies obtained from a longitudinal, clinically well‐characterized cohort of PD patients and healthy controls (HC).
Cortical structural involvement and cognitive dysfunction in early Parkinson's disease
Magnetic resonance imaging (MRI) studies in early Parkinson's disease (PD) have shown promise in the detection of disease-related brain changes in the white and deep grey matter. We set out to establish whether intrinsic cortical involvement in early PD can be detected with quantitative MRI.
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