Skip To Main Content
C Spencer on Muck Rack

C Spencer

As seen in: BioRxiv, JNeurosci, Derbyshire Times
Back to C Spencer’s profile

Articles by C Spencer

Regulation of the mouse ventral tegmental area by melanin-concentrating hormone

|
By C Spencer, Melissa Chee
| JNeurosci Verified
Abstract Melanin-concentrating hormone (MCH) acts via its sole receptor MCHR1 in rodents and is an important regulator of homeostatic behaviors like feeding, sleep, and mood to impact overall energy balance. The loss of MCH signaling by MCH or MCHR1 deletion produces hyperactive mice with increased energy expenditure, and these effects are consistently associated with a hyperdopaminergic state.
Open in Who Shared Issue with article?

Inhibitory actions of melanin-concentrating hormone in the lateral septum

|
By C Spencer, Melissa Chee, Mikayla A Payant
| BioRxiv
Abstract Melanin-concentrating hormone (MCH) neurons can coexpress several neuropeptides or neurotransmitters and send widespread projections throughout the brain. Notably, there is a dense cluster of nerve terminals from MCH neurons in the lateral septum (LS) that innervate LS cells by glutamate release. The LS is also a key region integrating stress- and anxiety-like behaviours that are also emerging roles of MCH neurons.
Open in Who Shared Issue with article?

Regulation of the mouse ventral tegmental area by melanin-concentrating hormone

|
By C Spencer, Ralitsa Nikolova, Persephone A Miller, Jesukhogie G Williams-Ikhenoba
| BioRxiv
Abstract Melanin-concentrating hormone (MCH) acts via its sole receptor MCHR1 in rodents and is an important regulator of homeostatic behaviors like feeding, sleep, and mood to impact overall energy balance. The loss of MCH signaling by MCH or MCHR1 deletion produces hyperactive mice with increased energy expenditure, and these effects are consistently associated with a hyperdopaminergic state.
Open in Who Shared Issue with article?
Show More