Dear Editor, We read with great interest the study by Wongkanong et al., which developed a multivariable fractional polynomial interaction (MFPI) logistic regression model to predict advanced colorectal neoplasia (ACN) in asymptomatic Thai adults aged 40 years or older, integrating seven routinely collected clinical variables (age, sex, body mass index, diabetes mellitus, smoking, alcohol use, and family history of colorectal cancer in first degree relatives) [1].
