AA anti-aging AE adverse event CHMP Committee for Medicinal Products for Human Use CO2 carbon dioxide D1, D8, M1, M2, and M3 Day 1, Day 8, Month 1, Month 2, and Month 3, referring to study time points EMA European Medicines Agency FAS full analysis set GCP Good Clinical Practice HA hyaluronic acid HRIPT Human Repeated Insult Patch Test IL interleukin NRS numerical rating scale ROS reactive oxygen species SASP senescence-associated secretory phenotype SEM standard error of the mean 1...