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Located within the human Major Histocompatibility Complex (MHC) on the short arm of chromosome 6p21.3, the HLA locus is the most gene dense and polymorphic region in the human genome with over 420 genes and 43,758 alleles described in the 7.6 Mb region. The significant diversity of alleles is due to amino acid substitutions in the peptide binding grooves.
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