Pathogenesis and Immunity Aurélien Chuard, Katia Courvoisier-Guyader, Sylvie Rémy, Stephen Spatz, Caroline Denesvre, David Pasdeloup Felicia Goodrum, Editor DOI: 10.1128/JVI.01645-20 ABSTRACT Viral tropism and transmission of herpesviruses are best studied in their natural host for maximal biological relevance. In the case of alphaherpesviruses, few reports have focused on those aspects, primarily because of the few animal models available as natural hosts that are compatible with such studies.