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Abstract Amyotrophic lateral sclerosis is a fatal neurodegenerative disease increasingly linked to T cell responses, although the mechanisms driving T cell activation and disease progression remain unclear.
ALS amyotrophic lateral sclerosis ALSFRS-R ALS Functional Rating Scale-Revised ATC anatomical therapeutic chemical BBB blood–brain barrier BMI body mass index CI confidence interval CNS central nervous system HAD Hospital Anxiety and Depression HR hazard ratio LISA The longitudinal integrated database for health insurance and labor market studies MND motor neuron disease MoCA Montreal Cognitive Assessment OR odds ratio SK-ECAS Edinburgh Cognitive and Behavioral ALS Screen Background...
1 Introduction Motor neuron disease (MND) is a relatively rare neurodegenerative disease characterized by the loss of upper and lower motor neurons, leading to a decline in various motor functions [1]. MND is comprised of amyotrophic lateral sclerosis (ALS), accounting for approximately 90% of cases, primary lateral sclerosis (PLS), progressive spinal muscular atrophy (PSMA), and other MNDs [2].
Abstract Objective To determine whether lipids and apolipoproteins predict prognosis of patients with amyotrophic lateral sclerosis in a cohort study of 99 patients with amyotrophic lateral sclerosis who were diagnosed during 2015 to 2018 and followed up until October 31, 2018, at the Neurology Clinic in Karolinska University Hospital in Stockholm, Sweden.
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