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Catarina I. G on Muck Rack

Catarina I. G

As seen in: MDPI, EJNMMI Research
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Articles by Catarina I. G

Evaluation of the theranostic potential of [64Cu]CuCl2 in glioblastoma spheroids - EJNMMI Research

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By Catarina I. G, André M, da Silva, Instituto Técnico
| EJNMMI Research Verified
Three glioblastoma cell lines were selected to establish spheroids, including two cell lines that are known to be tumorigenic in nude mice, U373 and U87, and a non-tumorigenic line, T98G. RA were used as a non-tumoral control. All the cell lines were able to form compact cell aggregates with a spherical form (Additional file 1: Fig. S1). Spheroids derived from the U87 cell line were the only ones that grew in size throughout the eleven-day culture period.
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Cancer 3D Models for Metallodrug Preclinical Testing

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By Filipa Mendes, Diogo M. Engrácia, Catarina I. G
| MDPI
Abstract : Despite being standard tools in research, the application of cellular and animal models in drug development is hindered by several limitations, such as limited translational significance, animal ethics, and inter-species physiological differences. In this regard, 3D cellular models can be presented as a step forward in biomedical research, allowing for mimicking tissue complexity more accurately than traditional 2D models, while also contributing to reducing the use of animal models.
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