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1 In the stage 1 IPA this read ‘heterogeneity’, which was a typo. 2 In the stage 1 IPA this read ‘conditional total effect’. All effects calculated in this paper are conditional, so this word was removed to avoid confusion. 3 Deviation: this data range was expanded during data collection with approval from the editor. This range was chosen to meet the required sample size for the indication matched comparison after false positive terms were excluded.
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