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ACTIVE TARGETING The next generation of FGS agents—active tracers—target specific epitopes on tissues of interest. Pafolacianine is a near-infrared molecule that binds to folate receptors α and β, which are highly expressed by a variety of tumors.
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To explore the hypothesis that dysregulated mitochondrial dynamics may impact drug sensitivity, we began by examining the alteration status of six canonical dynamics-regulating genes - OPA1, MFN1, MFN2, FIS1, MFF, and DNM1L (which encodes Drp1)—in human cancers.
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