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Highlights • Balloon-expandable TAVI is likely to be cost-effective vs SAVR in Italian low risk sSAS patients. • TAVI offers benefits over SAVR with an ICER/QALY gained of €2532 per patient. • In sensitivity analyses, TAVI was cost-effective in 100% of Monte Carlo simulations. • Major cost drivers were TAVI procedure costs and starting age of the model cohort.
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