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1 INTRODUCTIONS Cellular protein homeostasis is intricately regulated, with proteasome-mediated degradation and lysosomal-mediated proteolysis serving as prominent pathways for eliminating abnormal or damaged proteins.1 Over the past decades, the ubiquitin-proteasome system (UPS) has emerged as a therapeutic target for various human cancers.2-9 The pivotal role of UPS in cancer has been extensively documented,10, 11 and a growing body of research suggests that targeting the UPS holds promise...
MCF10A, MCF7, T47D, BT474, MDA-MB-453, BT549, MDA-MB-468, HCC1806, MDA-MB-231, and human embryonic kidney HEK-293T cell lines were purchased from the Chinese National Infrastructure of Cell Line Resource (Beijing, China). All human cell lines were authenticated using STR DNA fingerprinting at Shanghai Biowing Applied Biotechnology Co., Ltd. (Shanghai, China). MCF7, T47D, BT474, MDA-MB-453, BT549, MDA-MB-468, HCC1806, MDA-MB-231, and HEK-293T were maintained in DMEM supplemented with 10%FBS (Gibco).
Abstract Myoepithelium plays an important role in mammary gland development, but less is known about the molecular mechanism underlying how myoepithelium controls acinus differentiation during gestation. Herein, we found that loss of Kindlin-2 in myoepithelial cells impaired mammary morphogenesis, alveologenesis, and lactation.
Abstract The methyltransferase like 3 (METTL3) has been generally recognized as a nuclear protein bearing oncogenic properties. We find predominantly cytoplasmic METTL3 expression inversely correlates with node metastasis in human cancers. It remains unclear if nuclear METTL3 is functionally distinct from cytosolic METTL3 in driving tumorigenesis and, if any, how tumor cells sense oncogenic insults to coordinate METTL3 functions within these intracellular compartments.
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