Cancers display hallmarks of spatial and temporal heterogeneity at various scales, contributing to unfavorable prognosis and treatment failure.1 Clinical imaging offers the possibility of elucidating multifaceted phenotypic aspects of cancer structure and physiology through acquisition of diverse modalities.1-3 Semantic features such as descriptors of size, morphology, and location that are commonly measured from radiologic images, are limited in revealing the underlying cancer...