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Abstract Peritoneal metastasis (PM) and the resulting malignant tumour ascites characterize advanced gastrointestinal cancers, often leading to poor prognosis and limited response to current therapies. Single-cell analysis of patient-derived PM and malignant tumour ascites reveals an approximately 90% enrichment of TREM2+-tumour-associated macrophages, which drive CD8+ T cell dysfunction and tumour growth.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.