Published In Science Volume 383 | Issue 6684 16 February 2024 Article versions Submission history Received: 15 December 2022 Accepted: 13 December 2023 Published in print: 16 February 2024 Permissions Request permissions for this article. Acknowledgments We thank J. Lingner for generous gifts of HeLa-superT cells and purified telomerase. We thank J. Maciejowski, M. Imieliński, D. Hockemeyer, D. Cortez, T. Cech, and members of the de Lange laboratory for helpful discussions of this work.