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Articles by Charles Sinclair
Applications of Flow Cytometry in Drug Discovery and Translational Research
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
KENT AVE. WALL IRKS COUNCIL
Dispatchist News from around the globe in real time Client login News Sources Countries People Categories Organizations “If you drive on Kent Avenue, there is a development that is taking place which started some time ago and which there were issues with it as NEPA had served notice and I believe it was taken to court,” said Sinclair.Without naming who is behind the development, he said there was continuation of the activity with additional dumping taking place into the sea to create land...
Maintaining Your Company Culture During Growth
By Charles Sinclair, Co-Founder and Head of Employer Branding at Oddwork. Company culture can be defined as a set of mutual beliefs and values that impact behavior. Your company culture sets the tone for your work environment, how your team interacts and how you are perceived by others.
The Value Of An Employer Branding Structure
Today, job searching, talent research, company culture and corporate values play a much larger role for organizations than ever before. Companies will have to realize the many values in creating strong company cultures and employer brands if they are interested in attracting this generation's top talent. This was the realization that dawned on my company six years ago. Having started as a recruiting startup, our job was to attract talent and connect them with their next career adventure.
mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation
Antigen-presenting cells (APCs) are scattered throughout the body in lymphoid organs and at the portals of pathogen entry, where they act as sentinels of the immune system. Sinclair et al. demonstrate that APCs at different sites have distinctive metabolic signatures and that the development and function of these cells are determined not only by their transcriptional program, but also by their metabolic state (see the Perspective by Wiesner and Klein).
mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation
Antigen-presenting cells (APCs) occupy diverse anatomical tissues, but their tissue-restricted homeostasis remains poorly understood. Here, working in mouse models of inflammation, we found that mTOR-dependent metabolic adaptation was required at discrete locations. mTOR was dispensable for DC homeostasis in secondary lymphoid tissues but necessary to regulate cellular metabolism and accumulation of CD103+ DCs and alveolar macrophages in lung.
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